Biomedical Engineering Reference
In-Depth Information
TABLE 3.2 (continued)
List of 44 Marketed Nano-Delivery Products
Product
Generic
Formulation
Indication
Manufacturer
Myocet
Doxorubicin citrate
complex
Liposome
encapsulated
Cancer chemotherapy
Cephalon/Zeneus
Pharma/Sopherion
Therapeutics
Megace ES
Megestrol acetate
Nanocrystal
formulation
Cancer therapy
Elan/
Alkermes + Par + Bristol-
Myers Squibb
MuGard
Hydrogel mouth rinse
Nanogel
Head and neck cancers
Access Pharma
Naprelan
Naproxen
Nanocrystal
formulation
Arthritis, gout
Elan/Alkermes
Nanoxel
Paclitaxel
Polymeric
nanoparticles
Cancer chemotherapy
Dabur Pharma
Neulasta
Filgrastim
Pegylation
Neutropenia
Amgen
Oncospar
Oncospar
PEG-Lasparaginase
Pegylation
Cancers
Enzon/Schering-Plough
Pegasys
Peginterferon alfa 2a
Pegylation
Hepatitis B, hepatitis
C
Roche/Nektar
PegIntron
Peginterferon alfa 2b
Pegylation
Chronic hepatitis C
Schering-Plough
Rapamune
Sirolimus
Nanocrystal
formulation
Immunosuppression
Wyeth Élan/Alkermes
Renagel
Sevelamer HCl
Poly (allylamine)
resin
Hyperphosphatemia in
hemodialysis
Genzyme
Salinum
Potassium,
magnesium, chlorine
Oral liquid
Xerostomia
Somavert
Pegvisomant
Polymer protein
conjugate
Acromegaly
Pfizer
Ritalin LA
Methylphenidate HCl
Pulsatile release
Nanocrystal
formulation
ADHD
Elan/Novartis
Survanta
Beractant
Liposome
encapsulated
Neonatal respiratory
distress
Abbott
Tricor
Fenofibrate
Nanocrystal
formulation
Lipid reduction
Abbott Élan/Alkermes
Triglide
Fenofibrate
Nanocrystal
formulation
Lipid reduction
SkyePharma/First Horizon
Pharmaceuticals/Sciele
Pharma
Verelan/
Verelan PM
Verapamil
Elan's SODAS
Multiparticulate
technology
Hypertension
Elan/Alkermes Schwarz
Source:
Data from www.bccresearch.com
3.4 NANOPARTICLES: PHYSICOCHEMICAL CHARACTERISTICS (PROPERTIES)
AND THEIR MULTIDIMENSIONAL ISSUES
Nanoparticles have specific physical, chemical, and biological properties. These unique properties
make them ideal molecules for diagnostics and therapeutics in modern medicine. Because of these
desirable properties, nanoparticles have wide applications in the industrial, medical, and cosmetic
fields. Nanoparticles have the ability to penetrate lung or dermal barriers, and translocate within
and damage living organisms. This is due to their small size, which makes them able to cross
