Chemistry Reference
In-Depth Information
There is less information about the secondary structures of RNAs. It is known that the RNA
molecules are lower in molecular weight than are the DNA molecules. In addition, it is known that
there are three main types of RNAs in living cells. These are
ribosomal
RNA (r-RNA),
transfer
RNA
(t-RNA), and
RNA (m-RNA). The molecular weights of the three forms on the average are
about 1,000,000, 25,000, and 500,000, respectively. RNA molecules, with the help of hydrogen
bonding, take three-dimensional cloverleaf structures [
54
]. The molecule's three-dimensional shape
also assumes an L-shape, into which the cloverleaf is bent.
messenger
8.6.2 Synthetic Methods for the Preparation of Nucleic Acids
Over the last 20-30 years, methods were developed to synthesize short deoxyribonucleotide chains
[
57
]. One synthetic procedure can be illustrated as follows:
O
NH
2
H
N
N
N
C
O
NN
O
N
N
O
3
N
O
+
O
P
O
O
OH
OH
O
O
O
O
H
H
N
N
N
O
N
O
O
O
HO
O
1. OH
NH
NH
2..H
N
N
N
N
O
O
N
N
O
P
O
N
N
O
P
O
O
O
O
O
O
O
O
O
