Chemistry Reference
In-Depth Information
Robustness:
A measure of a method's ability to withstand small but deliber-
ate changes in the method parameters; provides an indication of its
reliability during normal usage.
Separation factor:
A measure of the ability of the system to separate two
components within a mixture.
Solid phase extraction:
A process used to separate compounds from a mix-
ture based on their chemical and physical characteristics.
Solubility:
A measure of the amount of solid required to be added to a given
volume of solvent in order to form a saturated solution.
Specificity:
A method's ability to measure, without doubt, an analyte in the
presence of other materials that might be expected to be present in
the sample matrix.
Stationary phase:
Typically refers to the liquid-coated capillary columns.
The choice of stationary phase influences the chromatographic
separation.
Theoretical plate:
A hypothetical zone within a GC column. The greater
the number of theoretical plates within a column is the better the
separating power will be.
Validation:
Confirms that the method and the equipment consistently meet
the requirements for a specific use and are fit for purpose.
Van der Waals forces:
The weak electric forces of attraction or repulsion
that exist between neutral molecules.