Environmental Engineering Reference
In-Depth Information
Substance
Is substance a non-isolated
intermediate, under customs supervision,
radioactive, or a polymer?
Y
STOP
N
> 1 tonne/year?
STOP
N
Y
Other available
physiochemical,
toxicological and
ecotoxicological information
Methods of detection and analysis
Physiochemical
properties
Toxicological
information
Ecotoxicological
information
Corrosive, strong
acid/ base, flammable,
very toxic, or skin irritant;
and >10 tonne/year?
Skin irritation/corrosion
Assessment of:
human/animal data
acid or alkaline reaction
Substance state Melting/freezing point
Boiling point Relative density
Vapour Pressure Surface tension
Water solubility Flash-point
Flammability Explosive properties
Self-ignition temperature
Oxidising properties Granulometry
Partition coefficient n-octanol/water
< 10 tonnes/years
and insoluble or does not
cross biological
membranes?
Aquatic toxicity
Short-term toxicity testing (Daphnia)
Long-term toxicity testing (Daphnia)
Long-term toxicity testing (fish)
N
Eye irritation
Assessment of:
human/animal data
acid or alkaline reaction
Y
Relevant
in vivo
study
Growth inhibition study (algae)
Short-term toxicity testing (fish)
Activated sludge respiration
inhibition testing
Ready biodegradability
Degradation in surface water
Soil simulation testing
Sediment simulation testing
Positive result or
> 100 tonnes/year?
Mutagenicity
In vitro gene mutation
In vitro cytogenicity
In vitro gene mutation
> 10 tonnes/year?
Y
In vivo
mutagencity
studies
Y
> 100 tonne/year?
N
Y
N
> 10 tonnes/year?
N
Positive result or
> 100 tonnes/year?
Hydrolysis as a function of pH
> 100 tonnes/year?
Stability in organic
solvents
Dissociated constant
Viscosity
Y
N
Y
Y
Acute toxicity
Oral/dermal/inhalation route
Short-term repeated dose toxicity
Sub-chronic toxicity study
Reproductive toxicity screening
Developmental toxicity study
Toxicokinetics
Identification of degradation
products
Further degradation testing
2-generation
reproductive study
Environmental fate/behaviour
Adsorption/desorption
Bioconcentration (fish)
Further studies on adsorption/desorption
Short-term toxicity to earthworms/plants
Effects on soil microorganisms
Long-term toxicity on
earthworms/plants/soil invertebrates
> 1000 tonnes/year?
> 10 tonnes/year?
Y
> 100 tonnes/year?
Y
Y
N
Carcinogenicity study
N
Chemical Safety Assessment
Y
N
Long-term toxicity (sediment organisms)
Long-term/reproductive toxicity (birds)
> 1000 tonnes/year?
Chemical Safety Report
Figure 10.A.1
Overview of risk assessment by REACH showing information triggers (taken from Rocks et al., 2008).
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