Biomedical Engineering Reference
In-Depth Information
NPs has been the lack of knowledge about the distribution and location of
targeted NPs after either oral administration or injection. These important
steps in a nanoplatforms-based drug delivery should be investigated to im-
prove knowledge about systemic ways of administration and their advan-
tages and limits, as well as acute and chronic local and systemic toxic effects.
Most studies have not examined the targeting efficiency of NPs in vivo in
real time, and thus precise bio-distribution and subsequently therapeutic
effects are not well-known. Therefore, detecting malignant cells in the body
and monitoring treatment effects on these cells in real time is another chal-
lenge needed to be overcome in the development of efficient targeted NPs.
