Biomedical Engineering Reference
In-Depth Information
nanoparticles and the size of the nanoparticle itself can be modulated to
control the loading/releasing of the encapsulated or covalently linked drug
components or to add surface coating. Moreover, they can improve the effi-
cacy of existing imaging and treatment regimens. The ability to deliver con-
trast or therapeutic agents selectively to tumors at effective concentrations
is a key factor for the efficacy of cancer detection and therapy. Additionally,
encapsulation of drugs within nanoplatforms can provide a significant ad-
vantage when employing poorly soluble, poorly absorbed or labile agents by
incorporating them in the matrix of the nanoparticle during the formula-
tion/synthetic process.
This study presents a review of the recent studies of nanoparticle systems
in cerebral gliomas treatment with a particular emphasis on the develop-
ment of nanocarrier drug delivery systems for brain cancer therapy appli-
cations. These technologies include polymeric and polymer-drug conjugate
nanoparticles, micelle nanoparticles, liposomes, metallic and magnetic
nanoparticles, metal oxide, carbon derivates, peptide nanoparticles, inor-
ganic nanopaerticles, quantum dots, and dendrimers.
