Agriculture Reference
In-Depth Information
4
Expression and
Manufacture of
Pharmaceutical Proteins
in Genetically Engineered
Horticultural Plants
Qiang Chen
CONTENTS
A.Brief.History......................................................................................................... 84
Plants.Provide.a.New.Manufacturing.Technology.for.Pharmaceutical.Proteins......... 85
Protein.Pharmaceutical.Production.Using.Plant.Systems........................................ 88
Monoclonal.Antibodies........................................................................................ 89
Vaccines............................................................................................................... 92
Glycosylation.of.Plant-Made.Pharmaceuticals......................................................... 95
Downstream.Processing.of.Plant-Derived.Protein.Pharmaceuticals........................ 96
Column.Chromatography.................................................................................... 97
Nonchromatographic.Separations...................................................................... 101
Plant.Species.Used.for.PMP.Production................................................................ 103
Leafy.Crops....................................................................................................... 104
Seed.Crops......................................................................................................... 105
Fruit.and.Tuber.Crops........................................................................................ 106
Aquatic.Plants.................................................................................................... 107
Plant.Suspension.Cell.Cultures.and.Single-Cell.Cultures.of.Algae.................. 107
Regulatory.Concerns.and.Public.Acceptance......................................................... 108
Better.Stewardship.of.the.PMP.Community...................................................... 109
Alternative.PMP.Production.Technology.and.Risk.Control.............................. 109
Nonbiological.Containment.......................................................................... 109
Biological.Containment................................................................................ 110
Regulatory.Policies.regarding.PMP................................................................... 112
Conclusion.............................................................................................................. 112
References.............................................................................................................. 113
83
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