Biomedical Engineering Reference
In-Depth Information
Figure 10.5
Two-compartment system with elimination in the fi rst compartment.
C
(10.22)
AB
−
Bt
−
At
Ct
()
=
P
0
⎡
e
−
e
⎤
⎣
⎦
T
−
where
1
(
)
(
)
2
⎡
⎤
A
=
k
+
k
+
k
+
k
+
k
+
k
−
4
k k
⎢
⎥
p
T
e
⎣
p
T
e
T
e
⎦
2
and
1
(
)
(
)
2
⎡
⎤
B
=
k
+
k
+
k
−
k
+
k
+
k
−
4
k k
⎢
⎥
p
T
e
⎣
p
T
e
T
e
⎦
2
Dose
Equation (10.21) is a four-parameter (
k
T
, A, B
) and the lumped
C
=
(
)
p
0
VAB
−
D
model.
Other parameters can be obtained through:
AB
k
=
(10.23)
e
k
T
(
)
(
)
kABkk
=+− +
(10.24)
p
T
e
Dose
V
=
(10.25)
D
CAB
0
(
−
)
P
and
