The Biophysical Basis of Firing Variability in Cortical Neurons - Computational Neuroscience: A Comprehensive Approach - page 164

A

50 mV

B

10nS

300 ms

C

Figure 6.4
Spike time variability in responses of a layer V pyramidal neuron to a natural-like
burst conductance input. (A) An example membrane potential response to a burst
conductance input at the soma. (B) Conductance input consisting of a train of uni-
tary AMPA+NMDA conductance transients, generated by a nonstationary Poisson
process with an exponentially declining rate. Initial peak rate was 2500 Hz, time
constant was 500 ms. Total number of unitary input events was 1222. AMPA (thin
trace) and NMDA (thick trace) conductance components are shown separately. The
NMDA input is subject to a further voltage-dependent block (see Figure 6.8 ). (C)
Raster display of 32 trials with the same stimulus. From [48] with permission.