Biomedical Engineering Reference
In-Depth Information
Figure 3.6
The biochemical reaction scheme for activation of the calcium-dependent transcrip-
tion factor calcineurin. The top half of the figure described nuclear reactions (sub-
script n) and the bottom half describes cytosolic reactions (subscript c). At rest,
NFAT is phosphorylated. Upon activation by calcium, calcineurin (C) binds NFAT
and dephsophorylates by allowing its translocation into the nucleus. The transcrip-
tionally active form of NFAT is dephosphorylated and nuclear and is enclosed in a
box. The resting form is the phosphorylated cytoplasmic state, which is enclosed in
an oval.
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