Chemistry Reference
In-Depth Information
TABLE 8.14 (continued)
Determination of Pharmaceuticals and Drugs at Carbon Paste Electrodes, Sensors, and Detectors: Survey of Methods and Selected Studies
Analyte
(Chemical
Form)
Classiication (Chem.
Speciication)
Type of CPE (Modiier)/
[Coniguration]
Technique
(Mode)
Experimental and Electroanalytical
Characterization, Selected Data; Notes
Sample(s)
Ref(s)
Methamphet-
amine
(hydrochloride)
Psycho-stimulant.ag..
(
N
-methyl-1-phenyl-propan-
2-amine)
CNT-ILE.(composite.el.).
[ctng..CNT.+.(MIM)PF
6
]
CV,.ECL
Studies.on.irrev..oxidn..and.adsorption.
carbon.moiety:.multi-wall.CNTs;.both.
constituents.in.reaction.with.Met.give.
ECL-signal;.LOD:.8.×.10
−9
.M;.RSD.=.3%
Model.solns.
[426]
Methimazole
Antihyperthyroidism.ag..
(subst..thioamide)
C/PO.(+Co
II
-SB)
CV,.DPV
SB:.Schiff.base.(new.type),.studies.on.
catalytic.effect;.pH.6;.LOD:.1.×.10
−6
.M
Clinical.prep.,.
pharms.,.human.
serum.(synth.)
[1591]
Methotrexate
Antileukemic.and.anticancer/
tumor.agent.
(subst. aminopteroyl-.
l-glutamic.acid)
(a).C/PO.(unm.)
(b).C/PO.(+HPpCD)
(a).CV,.DPV
(b).SWASV
(a).pH.3.(BR-buff.),.2.nM;.(a,b).studies.on.
redn..mechanism,.pH-effect
(b).Use.of.l-.and.d-enantioactivity;.
LOD: μM
(a).Model.solns.
(b).Com..tablets,.
injections.(CRM)
(a).[2590,.
2591]
(b).[2592]
Metoclopramide
.
(hydrochloride)
Gastroprokinetic.and.
anti-migrene.agent.(sb..
OMe-benzamide)
C/PO.(+gly-PP)
CV,.SWASV
Studies.on.oxidn..mechanism.and.accum.
modif.:.glycosylated.porphyrin;.s.e.:.0.4.M.
HCl.+.AcB;.lin.:.0.07-270.μg.L
−1
pharm..forms..
(dosage.tablets)
[2593]
Metronidazole
.
(benzoate)
Antiprotozoal.agent.
(imidazole-ethanol)
(a).C/PO.(+gly-PP)
(b).C/PO.
(+Zn
II
-MHP-PP)
(a).SIA-AD
(b).DPCV
(a).Studies.on.oxidn..mechanism,.lin.r.:.6.×.
10
−8
-0.003.M;.(b).MHP-PP:.tetra-.MeO-
OH-Ph.porphyrin,.LOD:.4.4.μM
(a,b).pharm..forms.
(c).Human.urine
(a).[1580]
(b).[2594]
Mifepristone
Glucocorticoid-based.receptor.
antagonist.(synth..steroid)
C/PO.(unm.).C/PO.(+ss-,.
dsDNA).[ft-D]
SIA-AD
2.×.10
−7
-2.×.10
−6
.M;.analytically.useful.
interaction.with.ds-DNA.only
pharm..forms..
(tablets)
[2595]
Minodixyl
Hair-restoring.agent.
(piperidin-pyrimidine)
C/Nj.(+lipids)
CV,.taV,.
pseudo-DPV
1.×.10
−8
-1.×.10
−6
.M.study.on.pH-effect,.
pKi.evaluation,.oxidn..process
pharm..forms
[1670]
Mitomycin-C
Chemotherapeutic.ag..(subst..
quino-aziridin.methyl.
carbamate)
C/PO.(+ss-,.dsDNA)
DPV,.SWV
detn..via.the.guanine.signal;.LOD:.μM.
level;.DNA/.C-SPE.also.tested.
Model.solns.
[2596]
Mitoxanthron
Antibioticum.
(anthraquinone der.)
C/PO.(unm.)
CV,.DPV
pH.10.(BR-buff.),.LOD:.2.×.10
−7
.M;.
studies.on.redn..mechanism,.pH-effect
Model.solns.
[2597]
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