Biomedical Engineering Reference
In-Depth Information
Fig. 2.
Expression of
I
K1
,
I
to
,
I
Kr
and
I
Ks
ion channel subunits in CMG cells, shown by RT-PCR
analysis of ion channel subunits.
a
The CMG cells expressed Kir2.1 before differentiation, and
they also expressed Kir2.2 at 6 weeks when they showed ventricular myocyte-like action poten-
tials.
b
K
v
1.4 subunit was expressed from 2 weeks, and K
v
2.1 subunit was expressed from 4
weeks. Expression of K
v
4.2 was detected 6 weeks after differentiation, but K
v
1.2, K
v
1.5 and
K
v
4.3 were not detected before or any time after differentiation.
c
Mouse ERG (MERG) was
expressed both before and after the differentiation.
d
CMG cells did not express K
v
LQT1 or
KCNE1 before or after differentiation.
