Biomedical Engineering Reference
In-Depth Information
Fig. 5.
Action potentials, calcium transients, and transmembrane ionic currents during 800 ms
of spontaneous electrical activity in the single rabbit SA nodal cell models of Noble et al. [62],
Wilders et al. [89], Demir et al. [11], and Dokos et al. [16].
a
Membrane potential (
V
m
).
b
Intracellular free calcium concentration ([Ca
2+
]
i
).
c
Net transmembrane current (
I
m
).
d
Delayed
rectifier potassium current (
I
K
) and L-type calcium current (
I
Ca,L
).
e
Fast sodium current (
I
Na
),
hyperpolarization-activated current (
I
f
), and T-type calcium current (
I
Ca,T
).
f
Sodium-potassium
pump current (
I
NaK
), sodium-calcium exchange current (
I
NaCa
), and sarcolemmal calcium pump
current (
I
p,Ca
).
g
Net background current (
I
b
) and its calcium, potassium, and sodium
components (
I
b,Ca
,
I
b,K
and
I
b,Na
, respectively). Data for the Demir et al. and Dokos et al. models
were obtained using the cellular open resource (COR) software [27].
