Chemistry Reference
In-Depth Information
TABLE 14.1 Major Strategies for Peptide Nanofiber Assembly
Orientation of Hydrogen
Bonding with Respect to
Fiber Axis
Secondary
Structure
Motif
Sequence Requirements
Method of Assembly
Coiled-coil
a-Helix
abcdefg heptad repeat
Hydrophobic packing (a & d residues)
guided by electrostatics (e & g residues)
Parallel
Amyloid-like
Antiparallel
b-sheet
a
Alternating hydrophilic/
hydrophobic
Hydrophobic nucleation followed by
hydrogen bond propagation
Parallel
Collagen-like
Polyproline
type II
(X-Y-Gly) repeat
Helix nucleation followed by zippering;
fiber formation still a significant
challenge
Perpendicular
Peptide-
amphiphile/
micelle
Parallel
b-sheet
b
Nearly any sequence with
terminal alkylation
Hydrophobic aggregation followed by
hydrogen bonding
Parallel
a
Some examples display a parallel hydrogen bonding organization.
b
Some examples display an anti-parallel hydrogen bonding organization.
