Biology Reference
In-Depth Information
titers in GBS are thought to be a result of the production of antibodies
to a bacterial carbohydrate-containing surface antigen that cross-reacts
with the myelin sheath, axons of nerve cells or non-ganglioside compo-
nents, but not clear in CIDP, resulting in demyelination and axonal
degeneration.
Analysis of the mimic structures of these crucial proteins (antigens)
should be helpful in understanding the induction of the anti-ganglioside
and anti-nonganglioside immune response that leads to GBS and related
autoimmune neuropathies, CIDP.
Acknowledgments
This study was supported by grants from the Swedish Medical Research
Council (K2007-62X-13133-09-3), the Swedish National Board of Health
and Welfare, and the Swedish Medical Association. We acknowledge the
invaluable assistance provided by Prof. Zhu at the Department of Neuro-
biology, Care Sciences and Society, in advising and editing the manuscript.
References
Allen D, Giannopoulos K, Gray I, Gregson N, Makowska A, Pritchard J,
Hughes RA. (2005) Antibodies to peripheral nerve myelin proteins
in chronic inflammatory demyelinating polyradiculoneuropathy.
J Peripher Nerv Syst
10
: 174-180.
Ang CW, Jacobs BC, Brandenburg AH, Laman JD, van der Meché FG,
Osterhaus AD, van Doorn PA. (2000) Cross-reactive antibodies
against GM2 and CMV-infected fibroblasts in Guillain-Barré
syndrome.
Neurology
54
: 1453-1458.
Ang CW, Laman JD, Willison HJ, Wagner ER, Endtz HP, de Klerk MA,
Tio-Gillen AP, van den Braak N, Jacobs BC, van Doorn PA. (2002)
Structure of
Campylobacter jejuni
lipo-polysaccharides determines
antiganglioside specificity and clinical features of Guillain-Barré and
Miller Fisher patients.
Infect Immun
70
: 1202-1208.
Search WWH ::
Custom Search