Biology Reference
In-Depth Information
Table 3.
Antibodies to Myelin and Nerve Proteins in CIDP
Antigens related
with auto-
References reporting
antibodies
auto-antibodies
Ig class
P0
Quarles et al. (1990)
IgM, IgG
Khalili-Shirazi et al. (1993)
Meléndez-Vàsquez et al. (1997)
Yan et al. (2001)
Kwa et al. (2001)
Allen et al. (2005)
P2
Hughes et al. (1984)
IgM, IgG
Khalili-Shirazi et al. (1993)
PMP22
Gabriel et al. (2000)
Ritz et al. (2000)
Kwa et al. (2001)
α + β-tublin
Manfredini et al. (1995)
IgM, IgG
β -tublin
Connolly et al. (1993)
IgM, IgG
van Schaik et al. (1995)
Connolly et al. (1997)
GD3
Usuki et al. (2005)
IgG
Connexin32
Kwa et al. (2001)
SGPG
Inuzuka et al. (1998)
IgM
LM1
Fredman et al. (1991)
Key: CIDP = chronic inflammatory demyelinating polyneuropathy.
In 1996, elevated IgM anti-SGPG antibody titer was found and proposed
as a diagnostic marker for a subgroup of patients with CIDP with or without
para-protein (Yuki et al ., 1996). Recently, Usuki et al . (2005) reported the IgG
antibody titer to GD3 was remarkably elevated (titer, 1:10 000), indicating
maximal activity to another tetrasaccharide epitope (-NeuAc
α
2-8NeuAc
α
2-
1-4Glc-). However, the exact mimicry mechanism should be look-
ing for, such as mimicry structure identification, in CIDP pathogenesis.
3Gal
β
Conclusion
In conclusion, CIDP and GBS with its variant, MFS, are autoimmune
neuropathies related to the auto-antibodies. Increased auto-antibody
 
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