Biology Reference
In-Depth Information
Table 3.
Antibodies to Myelin and Nerve Proteins in CIDP
Antigens related
with auto-
References reporting
antibodies
auto-antibodies
Ig class
P0
Quarles
et al.
(1990)
IgM, IgG
Khalili-Shirazi
et al.
(1993)
Meléndez-Vàsquez
et al.
(1997)
Yan
et al.
(2001)
Kwa
et al.
(2001)
Allen
et al.
(2005)
P2
Hughes
et al.
(1984)
IgM, IgG
Khalili-Shirazi
et al.
(1993)
PMP22
Gabriel
et al.
(2000)
Ritz
et al.
(2000)
Kwa
et al.
(2001)
α + β-tublin
Manfredini
et al.
(1995)
IgM, IgG
β -tublin
Connolly
et al.
(1993)
IgM, IgG
van Schaik
et al.
(1995)
Connolly
et al.
(1997)
GD3
Usuki
et al.
(2005)
IgG
Connexin32
Kwa
et al.
(2001)
SGPG
Inuzuka
et al.
(1998)
IgM
LM1
Fredman
et al.
(1991)
Key: CIDP = chronic inflammatory demyelinating polyneuropathy.
In 1996, elevated IgM anti-SGPG antibody titer was found and proposed
as a diagnostic marker for a subgroup of patients with CIDP with or without
para-protein (Yuki
et al
., 1996). Recently, Usuki
et al
. (2005) reported the IgG
antibody titer to GD3 was remarkably elevated (titer, 1:10 000), indicating
maximal activity to another tetrasaccharide epitope (-NeuAc
α
2-8NeuAc
α
2-
1-4Glc-). However, the exact mimicry mechanism should be look-
ing for, such as mimicry structure identification, in CIDP pathogenesis.
3Gal
β
Conclusion
In conclusion, CIDP and GBS with its variant, MFS, are autoimmune
neuropathies related to the auto-antibodies. Increased auto-antibody
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