Biomedical Engineering Reference
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Figure 10. Statistical parametric maps of T1 signal darkening with normal aging, obtained
using the RAVENS methodology for elastic registration. T1 darkening might be due to
a variety of factors, such as vascular disease, demyelination, mineral deposition, or other
degenerative processes. Reprinted with permission from [1]. Oxford UP. See attached CD
for color version.
multivariate nonlinear classification methods described in Section 4 above, we
have identified morphological signatures that are unique to the disease, and which
can potentially be used for early diagnostic purposes.
3.6.3. Neuroimaging of XXY children
In [4] we examined brain morphometry variation associated with XXY males
(Klinefelter's syndrome) by using an automated whole-brain volumetric analysis
method. The application to 34 XXY males and 62 normal male controls reveals
pronounced volume reduction in the brains of XXY males, relative to the brains of
normal controls, localized at the insula, temporal gyri, amygdala, hippocampus,
cingulate, and occipital gyri. Most of these statistically significant regions are
located in the gray matter structures, with the exception of one cluster of atrophy
involved in white matter structure, i.e., right parietal lobe white matter. Figure 11.
shows some representative results from the statistical analysis of the RAVENS
tissue density maps obtained in this study.
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