Chemistry Reference
In-Depth Information
4.7 Conclusions
The thiol-ene reaction has been demonstrated to have the potential to
functionalize FA derivatives with a wide array of functional groups. The re-
action is versatile and gives high yields when used with monounsaturated
acids. Despite that, there are still unresolved problems with the reaction;
especially the thiol-ene reaction with polyunsaturated FAs having bis-allylic
protons. Literature examples with such FAs are less common, and the re-
ported yields are lower, or the reaction conditions are harsher. The literature
review in this chapter shows that there are still some discrepancies and gaps
in the knowledge of the kinetics of the reaction.
The H-phosphonate-ene reaction also has promise for obtaining valuable
compounds but, at the current stage, the reaction is more limited in scope.
One of the problems is the lower reactivity, which is reflected in the fact that
there are no published isolated products of H-phosphonate-ene reactions
with polyunsaturated FAs. Another problem is the lack of availability of
multifunctional H-phosphonate compounds. There is also less knowledge
about the kinetics of H-phosphonate-ene reactions with double bonds
compared to reactions based on thiol-ene kinetics.
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