Chemistry Reference
In-Depth Information
46
47
48
A semisynthetic derivative of avermectine, 22,23-dihydroavermectin B1,
called ivermectin (
47
), is 1000 times more active than thiabendazole and is a
commercial veterinary product.
The avermectins are closely related to the milbemycins (
48
), a group of nong-
lycosylated macrolides produced by
Streptomyces hygroscopicus
subsp.
aureo-
lacrimosus
(23). These compounds possess activity against worms and insects.
3.4.2 Polyethers
Monensin is a polyether ionophore antibiotic (
49
) produced by
Streptomyces cin-
namonensis
. It is a narrow-spectrum antibiotic with extreme potency against the
