Chemistry Reference
In-Depth Information
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cyclopropylpyrroloindole moiety (18). Bizelesin cleaves doubled-stranded DNA
by binding noncovalently within the minor groove with a consensus sequence of
5
-d(A/GNTTA)-3
and 5
-d(AAAAA)-3
.
Prodigiosin is mainly isolated from
Serratia marcescens
, although it can be
also found in unrelated species such as
Vibrio psychroerythrus, Streptomyces
griseoviridis
,and
Hahella chejuensis
. Prodigiosin is a red pigment with a
pyrrolyldipyrrolylmethene moiety and a
-ring methoxy group (
41
), (dashed
rectangle) (20) that contains different alkyl substituents. In the presence of
reduced metal ions such asCu
2+
, prodigiosin is capable of cleaving single- and
double-stranded DNA. Prodigiosin functions via a mechanism similar to that
of CC-1065 and the bleomycins; however, it causes reductive activation of
molecular oxygen, forming reactive oxygen species such as hydrogen peroxide
that initiate the DNA cleavage (21).
β
