Chemistry Reference
In-Depth Information
30
31
Coleophoma empetri
. All of these antibiotics are characterized structurally by a
cyclic hexapeptide that is acylated with a long side chain. The difference between
FR901379 and other echinocandins is the presence of a sulfate moiety in its struc-
ture (
29
). Three echinocandins have reached the market, including caspofungin
(produced by
G. lozoyensis
)(
30
), micafungin (produced from FR901379), and
anidulafungin (synthesized from echinocandin B) (
31
).
3.3 ANTITUMOR COMPOUNDS
More than 60% of the anticancer drugs in clinical use are natural products derived
from microorganisms (17). Antitumor metabolites exhibit broad chemical diver-
sity and structural complexity.
