Chemistry Reference
In-Depth Information
was isolated from
Siphonochalina siphonella
, represents the first example of
this class. Adociasulfate-2 (
146
) is a member of the triterpenoid hydroquinone
sulfates isolated from a sponge
Haliclona
(aka
Adocia
) sp. that is the only
known natural product inhibitor of kinesin (12, 19).
CO
2
H
O
O
O
OH
H
H
O
O
O
OAc
O
OH
H
O
H
H
O
H
H
Br
HO
OH
O
H
H
144
143
145
NaO
3
SO
OSO
3
Na
O
H
H
O
O
OAc
O
O
H
MeO
2
C
O
H
O
O
O
146
CO
2
R
147
147
:R=CH
2
CH
2
SO
3
Na
148
148
:R=CH
3
O
O
OX
OH
OX
O
O
XO
O
Me
O
O
OX
Me
XO
Me
O
O
Me
O
O
O
O
O
O
O
O
XO
HO
O
XO
XO
XO
XO
OX
XO
OH
OX
OH
O
O
O
O
O
O
HO
O
OH
O
XO
O
XO
XO
O
O
XO
OH
XO
XO
O
Me
O
OH
X = SO
3
Na
149
OH
OH
149
Didemnaketal C (
147
) is an unusual heptaprenoid isolated from an ascid-
ian
Didemnum
sp.; its methanolysis product, didemnanaketal B (
148
), inhibited
HIV-1 protease (12).
2.4.5 Sugars
Several unusual polysaccharides have been isolated from sponges (11), among
which the most unusual is axinelloside A (
149
), which has been isolated recently
as a potent telomerase inhibiter from
Axinella infundibula
(12). It resembles
bacterial lipopolysaccharides.
