Chemistry Reference
In-Depth Information
was isolated from the sponge
Latrunculia
cf.
bocagei
. More than 20 alkaloids
of this class are known at moment (30). Additional examples of this family are
batzelline A (
80
) from a deep-sea sponge of the genus
Batzella
and wakayin (
81
)
from an ascidian
Clavelina
sp.
Marine pyridoacridines show a wide range of biological activities, namely
antimicrobial, antiviral, antiparasitic, insecticidal, antitumor, and enzyme inhi-
bitory (12, 29, 30).
2.3.4 Pyrrole Alkaloids
Highly substituted pyrroles are often found in sponges, ascidians, and mollusks
(30). Lamellarins A (
82
)-D are the first metabolites of this group that were
reported from a mollusk
Lamellaria
sp., followed by the discovery of more
than 50 alkaloids of this class from sponges and ascidians. Polycitone A (
83
)
was isolated from a tunicate
Polysitor
sp., whereas storniamide A (
84
)was
isolated from a sponge of the genus
Cliona
. The most recent addition to this
class is dictyodendrins A (
85
) through E isolated as telomerase inhibitors from
the sponge
Dictyodendrilla verongiformis
(12). Various bioactivities have been
reported for lamellarins and related compounds, which include antitumor, antivi-
ral, and enzyme inhibitory.
Br
Br
HO
OH
HO
O
O
OH
Br
Br
MeO
N
Br
Br
HO
HO
OH
N
OMe
O
O
MeO
Br
Br
OMe
MeO
882
OH
883
HO
H
O
O
H
OH
HO
OSO
3
Na
HO
OH
NH
O
N
N
MeO
OH
N
N
O
O
HO
OH
HO
OH
OH
OH
884
885
