Chemistry Reference
In-Depth Information
H
H
H
H
O
O
O
H
H
O
O
O
O
O
O
O
H
H
H
H
HO
H
O
H
H
O
O
O
HO
O
O
HO
228
OH
HO
HO
O
H
H
H
OH
O
O
OCH
3
O
HO
H
HO
O
Cl
O
H
H
O
O
H
O
AcO
OAc
OH
229
inhibit growth of tumor cells at sub-nM levels by binding to the vinca domain of
tubulin. Their low yields and occurrence in several different sponges suggest their
microbial origin. Spirastrellolide B (
30
) was reported recently as an antimitotic
agent from the sponge
Spirastrella coccinea
. It is actually a potent and selective
inhibitor of protein phosphatase 2A (12).
O
OCH
3
O
HO
OH
HO
O
OH
HO
CH
3
O
OCH
3
O
HO
OCH
3
O
O
OH
O
Cl
331
O
O
O
OH
HO
HO
O
OH
O
O
OH
O
OMe
O
HO
OCH
3
H
O
330
OH
O
O
332
