Chemistry Reference
In-Depth Information
134. Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong
Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J,
Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN. Identifi-
cation of an antimalarial synthetic trioxolane drug development candidate. Nature
2004;430:900-904.
135. Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux
B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle
JM, Tang Y, Wittlin S, Brun R, Vennerstrom JL. Spiro and dispiro-1,2,4-trioxolanes
as antimalarial peroxides: charting a workable structure-activity relationship using
simple prototypes. J. Med. Chem. 2005;48:4953-4961.
136. Perry CS, Charman SA, Prankerd RJ, Chiu FC, Dong Y, Vennerstrom JL, Charman
WN Chemical kinetics and aqueous degradation pathways of a new class of synthetic
ozonide antimalarials. J. Pharm. Sci. 2006;95:737-747.
137. Dong Y, Tang Y, Chollet J, Matile H, Wittlin S, Charman SA, Charman WN,
Tomas JS, Scheurer C, Snyder C, Scorneaux B, Bajpai S, Alexander SA, Wang X,
Padmanilayam M, Cheruku SR, Brun R, Vennerstrom JL. Effect of functional group
polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes. Bioorg.
Med. Chem. 2006;14:6368-6382.
138. Haynes RK. From artemisinin to new artemisinin antimalarials: Biosynthesis, extrac-
tion, old and new derivatives, stereochemistry and medicinal chemistry requirements.
Curr. Top. Med. Chem. 2006;6:509-537.
139. Shibata S, Fujita M, Itokawa H, Tanaka O. Studies on the constituents of Japanese
and Chinese crude drugs. XI. Panaxadiol, a sapogenin of Ginseng roots. Chem.
Pharm. Bull. 1963;11:759.
140. Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some
related triterpenoid compounds. J. Korean Med. Sci. 2001;16(suppl S):S28-S37.
141. Tanaka O. Ginseng and its congeners - Traditional oriental food drugs. In: Food Phy-
tochemicals for Cancer Prevention II, ACS Symposium Series 1994;547:335-341.
142. Lai DM, Tu YK, Liu IM, Chen PF, Cheng JT. Mediation of
β
-endorphin by gin-
senoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta
Med. 2006;72:9-13.
143. Yun TK, Choi SY. The relationship between cancer and ginseng intake. Intl. J.
Epidemiol. 1990;19:871-876.
144. Ellis JM, Reddy P. Effects of Panax ginseng on quality of life. Ann. Pharmacother.
2002;36:375-379.
145. Yun TK, Lee YS, Lee YH, Kim SI, Yun HY. Anticarcinogenic effect of Panax
ginseng CA Meyer and identification of active compounds. J. Korean Med. Sci.
2001;16(suppl S)S6-S18.
146. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology. Biochem. Pharmacol. 1999;58:
1685-1693.
147. Surh YJ, Na HK, Lee JY, Keum YS. Molecular mechanisms underlying anti-tumor
promoting activities of heat-processed Panax ginseng CA Meyer. J. Korean Med.
Sci. 2001;16(suppl S):S38-S41.
148. Sun H, Ye Y, Pan Y. Immunological-adjuvant saponins from the roots of Panax
notoginseng. Chem. Biodivers. 2005;2:510-515.
