Chemistry Reference
In-Depth Information
R
1
4
R
2
3
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
L1
Suksdorfin
L2
DCK, R
1
=
R
2
=
H
L3
4-MethylDCK, R
1
=
H
L4
3-Hydroxymethyl-4-methylDCK,
R
1
=
Me, R
2
=
Me, R
2
=
CH
2
OH
O
O
O
O
O
O
O
O
O
O
O
L5
DCP
Figure 14.12
Structures of anti-HIV coumarins.
the clinically approved RT inhibitors, such as AZT. Thus, these compounds
have a novel mechanism of action compared with current drugs. DCK and DCP
compounds could be useful in the treatment of AIDS, although additional inves-
tigation is merited and needed (116).
14.2.2 Syzigium claviflorum (triterpene betulinic acid derivatives)
Triterpenes represent a structurally varied class of natural products existing in
many plant species. Thousands of triterpenes have been reported with hun-
dreds of new derivatives described each year. Some naturally occurring triter-
penes exhibit moderate anti-HIV-1 activity and, therefore, provide good leads