Chemistry Reference
In-Depth Information
79. Brugada J, Brugada P, Brugada R. The ajmaline challenge in Brugada syndrome. A
useful tool or misleading information? European Heart J. 2003;24:1085-1086.
80. Stockigt J. Enzymatic biosynthesis of monoterpenoid indole alkaloids: ajmaline,
sarpagine and vindoline. Studies Organ. Chem. 1986;26:497-511.
81. Schmidt D, Stockigt J. Enzymatic formation of the sarpagan bridge: a key step in
the biosynthesis of sarpagine and ajmaline type alkaloids. Planta Med. 1995;61:
254-258.
82. Mattern-Dogru E, Ma X, Hartmann J, Decker H, Stockigt J. Potential active
site residues in polyneuridine aldehyde esterase a central enzyme of indole alka-
loid biosynthesis by modelling and site directed mutagenesis. Eur. J. Biochem.
2002;269:2889-2896.
83. Dogru E, Warzecha H, Seibel F, Haebel S, Lottspeich F, Stockigt J. The gene
encoding polyneuridine aldehyde esterase of monoterpenoid indole alkaloid biosyn-
thesis in plants is an ortholog of the a/b hydrolase super family. Eur. J. Biochem.
2000;267:1397-1406.
84. Pfitzner A, Stoeckigt J. Biogenetic link between sarpagine and ajmaline type alka-
loids. Tetrahedron Lett. 1983;24:5197-5200.
85. Gerasimenko I, Ma X, Sheludko Y, Mentele R, Lottspeich F, Stockigt J. Purification
and partial amino acid sequences of the enzyme vinorine synthase involved in a
crucial step of ajmaline biosynthesis. Bioorg. Med. Chem. 2004;12:2781-2786.
86. Bayer A, Ma X, Stockigt J. Acetyltransfer in natural product biosynthesis func-
tional cloning and molecular analysis of vinorine synthase. Bioorg. Med. Chem.
2004;12:2787-2795.
87. Ma X, Koepke J, Panjikar S, Fritzsch G, Stoeckigt J. Crystal estructure of
vinorine synthase, the first representative of the BAHD superfamily. J. Biol. Chem.
2005;280:13576-13583.
88. Falkenhagen H, Polz L, Takayama H, Kitajima M, Sakai S, Aimi N, Stockigt J.
Substrate specificity of vinorine hydroxylase, a novel membrane bound key enzyme
of Rauwolfia indole alkaloid biosynthesis. Heterocycles 1995;41:2683-2690.
89. Gao S, von Schumann G, Stockigt J. A newly detectedreductase from Rauvolfia
closes a gap in the biosynthesis of the antiarrhythmic alkaloid ajmaline. Planta Med.
2002;68:906-911.
90. von Schumann G, Gao S, Stockigt J. Vomilenine reductase: a novel enzyme catalyz-
ing a crucial step in the biosynthesis of the therapeutically applied antiarrhythmic
alkaloid ajmaline. Bioorg. Med. Chem. 2002;10:1913-1918.
91. Ruppert M, Woll J, Giritch A, Genady E, Ma X, Stoeckigt J. Functional expres-
sion of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus
expression system. Planta 2005;222:888-898.
92. Stockigt J, Pfitzner A, Keller PI. Enzymic formation of ajmaline. Tetrahedron Lett.
1983;244:2485-2486.
93. Li S, Long J, Ma Z, Xu Z, Li J, Zhang Z. Assessment of the therapeutic activity
of a combination of almitrine and raubasine on functional rehabilitation following
ischaemic stroke. Curr. Med. Res. Opin. 2004;20:409-415.
94. Costa-Campos L, Iwu M, Elisabetsky E. Lack of pro-convulsant activity of the
antipsychotic alkaloid alstonine. J. Ethnopharmacol. 2004;93:307-310.
