Chemistry Reference
In-Depth Information
(a)
(b)
Figure 9.2
(a) Representative terpenoid indole alkaloids. (b) Early biosynthetic steps
of the terpenoid indole alkaloid pathway yield the strictosidine, the central biosyn-
thetic intermediate for all terpenoid indole alkaloids. (c) Ajmaline biosynthesis. (d)
Ajmalicine and tetrahydroalstonine biosynthesis. (e) Vindoline biosynthesis from taber-
sonine. TDC, tryptophan decarboxylase; STR, strictosidine synthase; SGS, strictosidine
glucosidase; SB, sarpagan bridge enzyme; PNAE, polyneuridine aldehyde reductase;
VS, vinorine synthase; VH, vinorine hydroxylase; VR, vomilenine reductase; DHVR,
dihydrovomilenine reductase; AAE, 17-O-acetyl-ajmalanesterase; NMT, norajmaline-N-
methyltransferase; T16H, tabersonine-16-hydroxylase; HTOM, 16-hydroxytabersonine-
16-O-methyltransferase; NMT, N-methyltransferase; D4H,
desacetoxyvindoline-4-
hydroxylase; DAT, desacetylvindoline O-acetyltransferase.
