Chemistry Reference
In-Depth Information
CurA
CurF
CurB
CurC
CurD
CurE
AT
PhyH
ER
AT
3
GNAT
ACP
ACP
ACP
ACP
Cy
A
PCP
KS
ACP
ACP
KS
HMGS
ECH
1
ECH
2
KS
HMG Modification
JamC
JamE
JamJ
JamF
JamG JamH
JamI
7
AT
PhyH
ER
AT
DH
MT
ER
KR
ACP
ACP
ACP
KS
ACP
ACP
KS
HMGS
ECH
1
ECH
2
KS
ACP
HMG Modification
MmpB
MmpC
MmpA
C-term
MupH
MacpC MupG
MupJ
MupK
DH
KR
TE
9
ACP
ACP
ACP
ACP
KS
HMGS
ECH
1
ECH
2
KS
ACP
ACP
ACP
AT
KS
AT
9-HN synthesis (MmpB and others)
HMG Modification
VirA
C-term
VirF
VirG
N-term
VirI
VirB
VirC
VirD
VirE
?
KR
15
ACP
KS
ACP
ACP
KS
ACP
KS
ACP
AT
KS
HMGS
ECH
1
ECH
2
HMG Modification
PksC PksD
PksE
PksL
DH
DH
KR
ACP
KR
ACP
AcpK
PksF
PksG
PksH
PksI
1
AT
AT
AT
Ox
ACP
KS
ECH
1
ECH
2
ACP
KS
KS
ACP
ACP
KS
KS
HMGS
HMG Modification
DifA
DifB
DifL
DifM
MT
ER
DifC
Kinase
DifN
DifO
4
AT
Ox
ACP
ACP
KS
ACP ACP
TE
Oxy
ECH
2
HMGS
HMG Modification
Figure 7.6
HMGS containing biosynthetic pathways. Portions of the PKS and PKS/NRPS pathways where the HMGS and related enzymes are
located.
Abbreviations:
A — Adenylation, ACP — acyl carrier protein, AT — acyltransferase, Cy — cyclization, DH — dehydratase, ER — enoyl
