Chemistry Reference
In-Depth Information
Figure 6.2
(a) General architecture of NR PKS genes; proposed mechanism of, (b) the
WAS CLC domain, (c) the
Monascus purpureus
citrinin PksCT and
A. strictum
MOS
synthases; and (d) domain architecture of
A. terreus
and
P. patulum
MSAS, and proposed
mechanism of 6-MSA (
2
)andTAL(
44
).
domains that include cyclases, methyl transferases, and reductases. Thus, it seems
that these synthases are arranged with an N-terminal
loading component
; a cen-
tral
chain extension component
that consists of KS, AT, PT and ACP domains;
and a
C
-terminal
processing component
.
