Chemistry Reference
In-Depth Information
93
92
94
exclusive to IL-2 cytokine family receptors. Among prodiginines, prodigiosin (
93
)
is synthesized by
S. marcescens, Serratia plymuthica, H. chejuensis, Zooshikella
rubidus, Pseudomonas magnesiorubra
,and
V. psychroerythreus
(66-68).
Undecylprodigiosin (
94
) is produced by several actinomycetes such as
Strep-
tomyces coelicolor, Streptomyces longisporus rubber, Actinomadura madurae,
Streptoverticillium rubrireticuli
,and
Saccharopolyspora
sp. (67, 69, 70). Butyl-
meta-cycloheptylprodiginine (
95
), produced by
Saccharopolyspora
sp. nov. and
S. coelicolor
(67, 69), has a ring that is formed between positions 2 and 4 of
pyrrole ring C in prodigiosene (67). Cyclo-prodigiosin (
96
), produced by
Vib-
rio gazogenes, Alteromonas rubra
,and
Pseudoalteromonas denitrificans
,hasa
ring between positions 3 and 4 of pyrrole ring C and a methyl group at posi-
tion C-2. Cyclononylprodigiosin (
97
), produced by
Actinomadura pelletieri
and
Actinomadura madurae
(67), is a macrocyclic prodiginine with a ring formation
between position 2 of pyrrole C and position 10 of pyrrole A.
95
96
