Practical Aspects of Using NMR in Fragment-based Screening - Fragment-Based Drug Discovery - page 85

Figure 4.6 A schematic illustration of what impact various substitutions on BVT.1960 had on
the potency on A-FABP and selectivity against H-FABP. These findings were based on 11 close
analogues to BVT.1960. Adapted with permission from van Dongen et al., J. Am. Chem. Soc.,
124 , 11874. Copyright 2002 American Chemical Society.
Figure 4.7 Summary of the measured potencies for A-FABP and selectivities against H-FABP
for analogues of BVT.1960. The numbers are based on measurements using the fluorescence
polarization assay. Adapted with permission from van Dongen et al ., J. Am. Chem. Soc., 124 ,
11874. Copyright 2002 American Chemical Society.