Chemistry Reference
In-Depth Information
D. Winkler, NanoStore: a concept for logistical improvements of compound handling in
high-throughput screening,
J. Biomol. Screen
.,
10
, 573-580 (2005).
[52] T. Hesterkamp, J. Barker, A. Davenport and M. Whittaker, Fragment based drug discovery
using fluorescence correlation spectroscopy techniques: challenges and solutions,
Curr. Top.
Med. Chem
.,
7
, 1582-1591 (2007).
[53] J. Barker, T. Hesterkamp, M. Schade and M. Whittaker, Fragment screening: Biochemical
assays versus NMR,
Innov. Pharm. Tech
.,
23
, 19-22 (2007).
[54] P.J. Hajduk, J.R. Huth and S.W. Fesik, Druggability indices for protein targets derived from
NMR-based screening data,
J. Med. Chem.
,
48
, 2518-2525 (2005).
[55] http://www.active-sight.com/
[56] R.E. Armer and P.M. Cowley, Trends in medicinal chemistry 2004,
Drug News Perspect.
,
18
,
142-148 (2005).
[57] http://www.graffinity.com/
[58] M.R. Arkin, M. Randal, W.L. DeLano, J. Hyde, T.N. Luong, J.D. Oslob, D.R. Raphael,
L. Taylor, J. Wang, R.S. McDowell, J.A. Wells and A.C. Braisted, Binding of small molecules
to an adaptive protein-protein interface,
Proc. Natl. Acad. Sci. USA
,
100
, 1603-1608 (2003).
[59] R.E. Hubbard, presented at the Fragment-Based Drug Design Workshop, San Diego, CA, 13
May 2007.
[60] J. Fejzo, C.A. Lepre, J.W. Peng, G.W. Bemis, Ajay, M.A. Murcko and J.M. Moore, The
SHAPES strategy: an NMR-based approach for lead generation in drug discovery,
Chem. Biol.
,
6
, 755-769 (1999).