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[39] Maillaird, M., Hom, C., Gailunas, A., Jagodzinska, B., Fang, L. Y., John, V., Freskos, J. N.,
Pulley, S. R., Beck, J. P., Tenbrink, R. E. Preparation of substituted amines to treat Alzheimer's
disease. Patent WO2002002512, 2002.
[40] Patel, S., Vuillard, L., Cleasby, A., Murray, C. W., Yon, J. Apo and inhibitor complex structures
of BACE (-secretase).
J. Mol. Biol.
2004,
343
, 407-416.
[41] Hajduk, P. J. Fragment-based drug design: how big is too big?
J. Med. Chem.
2006,
49
,
6972-6976.
[42] Edwards, P. D., Albert, J. S., Sylvester, M., Aharony, D., Andisik, D., Callaghan, O., Camp-
bell, J. B., Carr, R. A., Chessari, G., Congreve, M., Frederickson, M., Folmer, R. H. A.,
Geschwindner, S., Koether, G., Kolmodin, K., Krumrine, J., Mauger, R. C., Murray, C. W.,
Olsson, L.-L., Patel, S., Spear, N., Tian, G. Application of fragment-based lead generation to
the discovery of novel, cyclic amidine -secretase inhibitors with nanomolar potency, cellular
activity and high ligand efficiency.
J. Med. Chem.
2007,
50
, 5912-5925.