Chemistry Reference
In-Depth Information
[25] Johnson, T. O., Ermolieff, J. and Jirousek, M. R. (2002). Protein tyrosine phosphatase 1B
inhibitors for diabetes.
Nat. Rev. Drug. Discov
.
1
, 696-709.
[26] Erlanson, D. A., McDowell, R. S., He, M. M., Randal, M., Simmons, R. L., Kung, J., Waight, A.
and Hansen, S. K. (2003). Discovery of a new phosphotyrosine mimetic for PTP1B using
breakaway tethering.
J. Am. Chem. Soc
.
125
, 5602-5603.
[27] Ockey, D. A. and Gadek, T. R. (2004). Discovery of novel PTP1B inhibitors.
Bioorg. Med.
Chem. Lett
.
14
, 389-391.
[28] Hinman, A., Chuang, H. H., Bautista, D. M. and Julius, D. (2006). TRP channel activation by
reversible covalent modification.
Proc. Natl. Acad. Sci. USA
103
, 19564-19568.
[29] Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F. and
Patapoutian, A. (2007). Noxious compounds activate TRPA1 ion channels through covalent
modification of cysteines.
Nature
445
, 541-545.
[30] Obita, T., Muto, T., Endo, T. and Kohda, D. (2003). Peptide library approach with a disulfide
tether to refine the Tom20 recognition motif in mitochondrial presequences.
J. Mol. Biol
.
328
,
495-504.
[31] Huc, I. and Lehn, J.-M. (1997). Virtual combinatorial libraries: dynamic generation of molecular
and supramolecular diversity by self-assembly.
Proc. Natl. Acad. Sci. USA
94
, 2106-2110.
[32] Hochgurtel, M., Kroth, H., Piecha, D., Hofmann, M. W., Nicolau, C., Krause, S., Schaaf, O.,
Sonnenmoser, G. and Eliseev, A. V. (2002). Target-induced formation of neuraminidase
inhibitors from
in vitro
virtual combinatorial libraries.
Proc. Natl. Acad. Sci. USA
99
,
3382-3387.
[33] Hochgurtel, M., Biesinger, R., Kroth, H., Piecha, D., Hofmann, M. W., Krause, S., Schaaf, O.,
Nicolau, C. and Eliseev,A. V. (2003). Ketones as building blocks for dynamic combinatorial lib-
raries: highly active neuraminidase inhibitors generated via selection pressure of the biological
target.
J. Med. Chem
.
46
, 356-358.
[34] Webb, M. E., Stephens, E., Smith, A. G. and Abell, C. (2003). Rapid screening by MALDI-
TOF mass spectrometry to probe binding specificity at enzyme active sites.
Chem. Commun
.,
2416-2417.
[35] Albert, A., Dhanaraj, V., Genschel, U., Khan, G., Ramjee, M. K., Pulido, R., Sibanda, B. L.,
von Delft, F., Witty, M., Blundell, T. L., Smith, A. G. and Abell, C. (1998). Crystal structure
of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self-
processing.
Nat. Struct. Biol
.
5
, 289-293.
[36] Roy, B. C., Hegge, R., Rosendahl, T., Jia, X., Lareau, R., Mallik, S. and Srivastava, D. K. (2003).
Conjugation of poor inhibitors with surface binding groups: a strategy to improve inhibition.
Chem. Commun
. 2328-2329.
[37] Roy, B. C., Banerjee, A. L., Swanson, M., Jia, X. G., Haldar, M. K., Mallik, S. and Srivastava,
D. K. (2004). Two-prong inhibitors for human carbonic anhydrase II.
J. Am. Chem. Soc
.
126
,
13206-13207.
[38] Jude, K. M., Banerjee,A. L., Haldar, M. K., Manokaran, S., Roy, B., Mallik, S., Srivastava, D. K.
and Christianson, D. W. (2006). Ultrahigh resolution crystal structures of human carbonic
anhydrases I and II complexed with 'two-prong' inhibitors reveal the molecular basis of high
affinity.
J. Am. Chem. Soc
.
128
, 3011-3018.
[39] Elling, C. E., Frimurer, T. M., Gerlach, L., Jorgensen, R., Holst, B. and Schwartz, T. W. (2006).
Metal ion site engineering indicates a global toggle switch model for seven-transmembrane
receptor activation.
J. Biol. Chem
.
281
, 17337-17346.
[40] Smar, M. W., Ares, J. J., Nakayama, T., Itabe, H., Kador, P. F. and Miller, D. D. (1992). Selective
irreversible inhibitors of aldose reductase.
J. Med. Chem
.
35
, 1117-1120.
[41] Chmura, A. J., Orton, M. S. and Meares, C. F. (2001). Antibodies with infinite affinity.
Proc.
Natl. Acad. Sci. USA
98
, 8480-8484.
