Biomedical Engineering Reference
In-Depth Information
(A)
(B)
Fig. 13.2.
Identification of the E2F4 target genes in WI38 cell.
(a)
Aclose-upofa
scanned image of the human DNA array that contains promoter regions of
∼
5000
human genes. The arrow points to a spot where the red intensity is significantly
higher than the green intensity, indicating that the promoter region of that gene
(EXO1) is bound in vivo by E2F4.
(b)
Scatter plot of Cy3-labelled total genomic
DNA versus Cy5-labelled E2F4 CHIP-enriched DNA. A P-value cutoff of 0.001 is
shown. The red spots represent some previously confirmed E2F4 targets, listed next
to the plot
