Chemistry Reference
In-Depth Information
Summary Box
Multivalent carbohydrate -protein interactions are responsible, at the molecular
level, for several crucial biological events, and mediate many important physi-
ological and pathophysiological processes. In spite of the weaknesses of these
interactions in terms of affi nity and selectivity on a per- saccharide basis, these
attractive forces are dramatically and naturally reinforced by a phenomenon
known as the 'glycocluster or dendritic effect'. In order to study, characterize,
understand and manipulate these critical multivalent interactions, multivalent
neoglycoconjugates based on several scaffolds such as peptides or proteins,
lipids, polymers or dendrimers have been synthesized using a large arsenal of
simple but effi cient chemical methods.
References
1
Mammen M
et al.
Polyvalent interactions
in biological systems: implications for
design and use of multivalent ligands and
inhibitors .
Angew Chem Int Ed Engl
1998 ;
37 : 2754 - 94 .
Gabius HJ. Glycans: bioactive signals
decoded by lectins.
Biochem Soc Trans
2008 ; 36 : 1491 - 6 .
Lee YC , Lee RT. Carbohydrate - protein
interactions: basis of glycobiology.
Acc
Chem Res
1995 ; 28 : 321 - 7 .
Nagahori N
et al.
Inhibition of adhesion of
type 1 fi mbriated
Escherichia coli
to highly
mannosylated ligands.
ChemBioChem
2002 ;
3 : 836 - 44 .
Roy R. The chemistry of neoglycoconju-
gates. In:
Carbohydrate Chemistry
9
Roy R. Blue - prints, syntheses and applica-
tions of glycopolymers.
Trends Glycosci Gly-
cotechnol
1996 ; 8 : 79 - 99 .
Roy R. Design and synthesis of glycoconju-
gates. In:
Modern Methods in Carbohydrate
Synthesis
(Eds.: Khan SH , O ' Neil RA ), pp.
378 - 402 . Harwood Academic , Amsterdam ,
1996 .
Ouchi T , Ohya Y. Drug delivery systems
using carbohydrate recognition. In:
Neogly-
coconjugates: Preparation and Applications
(Eds.: Lee YC , Lee RT ), pp. 465 - 98 . Aca-
demic Press, San Diego, CA, 1994.
Newkome GR
et al.
Dendrimers and Den-
drons: Concepts, Synthesis, Applications
.
Wiley - VCH , Weinheim , 2001 .
Fr é chet JMJ , Tomalia D.
Dendrimers and
Other Dendritic Polymers
. John Wiley &
Sons , New York , 2001 .
Duncan R , Izzo L. Dendrimer biocompati-
bility and toxicity.
Adv Drug Deliv Rev
2005 ;
57 : 2215 - 37 .
Touaibia M , Roy R. Application of multi-
valent mannosylated dendrimers in glycobi-
ology . In:
Comprehensive Glycoscience
(Ed.:
Kamerling JP ), pp. 821 - 70 . Elsevier , Amster-
dam , 2007 .
Roy R. A decade of glycodendrimer chemistry .
Trends Glycosci Glycotechnol
2003 ; 15 : 291 - 310 .
Turnbull WB , Stoddart JF. Design and
synthesis of glycodendrimers.
Rev Mol Bio-
technol
2002 ; 90 : 231 - 55 .
10
2
3
11
4
12
5
(Ed.:
13
Boons
GJ ),
pp.
243 - 321 .
Blackie
Aca-
demic , London , 1998 .
Bovin NV , Gabius H - J. Polymer immobi-
lized carbohydrate ligands versatile chem-
ical tools for biochemistry and medical
science .
Chem Soc Rev
1995 ; 24 : 413 - 21 .
Spain SG
et al.
Recent advances in the
synthesis of well-defi ned glycopolymers.
J
Polym Sci, Part A: Polym Chem
2007 ; 45 :
2059 - 72 .
Kobayashi K
et al.
Carbohydrate - contain-
ing polystyrenes. In:
Neoglycoconjugates:
Preparation and Applications
(Eds.: Lee YC ,
Lee RT ), pp. 261 - 84 . Academic Press , San
Diego, CA , 1994 .
6
14
15
7
8
16
17
