Chemistry Reference
In-Depth Information
Figure 4.8
Arylated glycondendron bearing
eight mannoside residues using a polylysine
scaffold and showing an IC
50
of 14
M against
μ
the FimH of
E. coli
K12 [4] .
several neoglycoconjugates in which carbohydrate residues are chemically or enzy-
matically attached to unnatural carriers. Organic chemistry is therefore at the
forefront of glycobiology by allowing access to novel architectures that can provide
a better and deeper understanding of biological processes involving carbohydrates.
This relatively new fi eld is open-ended since the chemists' imagination, coupled
with appropriate biological guidance, will offer new targets in their design and
applications.
