Chemistry Reference
In-Depth Information
Figure 29.3
Schematic diagram of the human
VWF receptor subunit GPIb
α
. A typical
N
- glycan
structure identifi ed on GPIb
is shown (inset
α
box).
such as Gal or
GlcNAc is detectable by their binding to specifi c lectins, for
example
Ricinus communis
agglutinin (RCA) I and succinylated wheat germ agglu-
tinin (sWGA) (for a survey of specifi cities of plant lectins, please see Table 18.1 ).
β
29.3
Cold - Induced Platelet Clearance
An effort to address the clinically relevant problem of why refrigerated platelets
fail to circulate led to the defi nition of a previously unsuspected, carbohydrate-
dependent platelet clearance mechanism. The hepatic macrophage carbohydrate-
binding integrin
subunits of the VWF
receptor following short-term (4h) platelet refrigeration, resulting in the phagocy-
tosis and clearance of platelets [8 - 10] . Experiments using
α
M
β
2
selectively recognizes clustered GPIb
α
α
M
- defi cient, but not
