Chemistry Reference
In-Depth Information
28.6
Conclusions
This chapter has discussed a range of diseases selected to demonstrate the value
of carbohydrate-based therapeutics. For many of these diseases no effective thera-
pies are currently available, emphasizing the need for the development of new
therapeutic strategies with new modes of actions. In many respects this area is
still in its infancy and it is likely that, as our understanding of the roles of carbo-
hydrates in biological systems improves, our ability to develop new carbohydrate-
based therapies will progress. The promising results presented here portray many
exciting therapies that are worthy of further study and many reports of carbohy-
drate-based therapeutics are likely to emerge in the forthcoming years.
Summary Box
Carbohydrates play many roles in biological systems, and therapies based on
them are fi nding value for diseases in which carbohydrates are involved. This
offers particular promise for treating cancer, viral and bacterial infections, dia-
betes, and thrombosis. Carbohydrate-based therapies are proposed to work by
a range of mechanisms, including inhibition of enzymes that are used to make
the disease-associated carbohydrates and blocking the interactions between the
disease-associated carbohydrate and the specifi c receptor.
References
1
Aarnoudse CA
et al.
Recognition of tumor
glycans by antigen-presenting cells.
Curr
Opin Immunol
2006 ; 18 : 105 - 11 .
Burger A .
Medicinal Chemistry and Drug
Discovery
, 6th edn , pp. 203 - 48 . Wiley Inter-
science , New York , 2003 .
Sapra P , Allen TM . Ligand - targeted liposo-
mal anticancer drugs.
Prog Lipid Res
2003 ;
42 : 439 - 62 .
Asano N
et al.
Sugar - mimic glycosidase
inhibitors: natural occurrence, biological
activity and prospects for therapeutic ap-
plication .
(lectins) in tumor metastasis.
Cancer Metas-
tasis Rev
2001 ; 20 : 245 - 77 .
McEver , RP . Selectin - carbohydrate interac-
tions during infl ammation and metastasis.
Glycoconj J
1997 ; 14 : 585 - 91 .
Botos I
et al.
Structures of the complexes of
a potent anti-HIV protein cyanovirin-N and
high mannose oligosaccharides.
J Biol Chem
2002 ; 277 : 34336 - 42 .
Larder BA
et al.
HIV with reduced sensitiv-
ity to zidovudine (AZT) isolated during pro-
longed therapy.
Science
1989 ; 243 : 1731 - 4 .
Hansen J - E
et al.
Complex Carbohydrates in
Drug Research (Alfred Benzon Symposium
36)
, pp. 414 - 27 . Munksgaard , Copenhagen ,
1994 .
Taylor DL
et al.
6 -
O
- Butanoylcastanosper-
mine (MDL 28,574) inhibits glycoprotein
processing and the growth of HIV.
AIDS
1991 ; 5 : 693 - 8 .
7
2
8
3
4
9
10
Tetrahedron: Asymm
2000 ; 11 :
1645 - 81 .
Lillelund VH
et al.
Recent developments
of transition - state analogue glycosidase
inhibitors of non-natural product origin.
Chem Rev
2002 ; 102 : 515 - 53 .
Gorelik E
et al.
On the role of cell surface
carbohydrates and their binding proteins
5
11
6
