Chemistry Reference
In-Depth Information
Table 27.6
Human siglecs and their properties.
Siglec
Synonyms
CD
Sialic acid
specifi city
(linkage type)
Number of
immunoglobulin
domains
Cellular
expression
Function
Siglec - 1
Sialoadhesin
CD169
a
17
Dendritic cells
b
,
monocytes
macrophages
-
2,3
>
2,6
>
2,8
Siglec - 2
-
CD22
2,6
6/7
c
B lymphocytes
Fine
modulation of
B lymphocyte
activation
Siglec - 3
-
CD33
2,6
>
2,3
2
Monocytes,
hematopoietic
precursors
Growth
regulation?
d
Siglec - 4
MAG
-
2,3
>
2,6
5
Schwann cells,
oligodendrocytes
Maintenance
of myeloid
sheath
Siglec - 5
-
CD170
2,3; 2,6
>
2,8
4
Monocytes,
granulocytes, B
lymphocytes
-
Siglec - 6
OB - BP1
CDw327
2,6 (CD175s)
3
B lymphocytes,
placenta
-
Siglec - 7
AIRM1
CDw328
2,8
>
2,6
>
2,3
3
Monocytes, NK
cells, T
lymphocytes
Regulation of
NK cell
cytotoxicity?
Siglec - 8
-
-
2,3
>
2,6
3
Eosinophils,
mast cells
-
Siglec - 9
-
CDw329
2,3; 2,6
3
Monocytes, NK
cells,
granulocytes
-
Siglec - 10
-
-
2,3; 2,6
5
Monocytes,
eosinophils, B
lymphocytes
-
Siglec - 11
-
-
2,8
5
Macrophages
-
a
2,3; 2,6, and 2,8 refer to the respective
α
-anomeric linkage of sialic acid to either galactose,
N
- acetylgalactosamine
or, in the case of
α
2,8, to sialic acid in subsequent
α
2,3 linkage.
b
DC = dendritic cells.
c
CD22 may occur in a short (six Ig domains, 130 kDa) or longer form (seven Ig domains, 140 kDa) [10] .
d
Myelin - associated glycoprotein.
