Chemistry Reference
In-Depth Information
longer considered as being purely phenomenological. In a broader biological
context, the defi nition of certain glycan epitopes as oncofetal antigens by applica-
tion of plant lectins/monoclonal antibodies means that they can embody signals
equally relevant during normal development (please see previous chapter and also
Chapters 22 and 23). Instead of constituting seemingly random deviations, the
emerging evidence on tumor- associated glycans signifi es that they - by (i) modulat-
ing protein activities and (ii) acting as docking sites for tissue lectins
- are an inte-
gral part of the tumor phenotype. As the examples given above teach us, the
accrued insights justify the perspective for devising innovative therapeutic
approaches. Hereby, we are already moving beyond positively answering the ques-
tion of this chapter ' s title.
Summary Box
Malignancy engenders multiple changes in glycosylation. The tumor-associ-
ated glycan remodeling can gain a functional dimension via (i) glycan- triggered
activity changes of distinct glycoproteins such as growth factor receptors or
integrins and (ii) lectin-mediated responses. Orchestration of glycan and lectin
expression with functional consequences is documented. The insights drawn
from model studies in tissue culture and from histopathology establish a per-
spective for innovative therapeutic approaches by rational manipulation of
glycan
/
lectin expression.
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