Chemistry Reference
In-Depth Information
Figure 23.7
Dysregulation of the TGF -
β
signal leads to emphysema in FucT-VIII KO mice.
Figure 23.8
Glycolipids absent in glycolipid synthase KO mice.
KO mice represents the sum of the loss of all glycosphingolipids except galacto-
lipids, resulting in embryonic death. In contrast, mice with KO of GM2/GD2
synthase, which is a key enzyme in the synthesis of complex gangliosides (Figure
23.8b), are born and develop apparently normally (please see also Chapter 30.3).
They are, however, sterile and show aspermatogenesis due to a disorder of testos-
terone transport. Although complex gangliosides completely disappear in the
