Chemistry Reference
In-Depth Information
Table 23.1
Mice of knockout of glycan - synthesizing enzymes.
Glycogenes and enzymes (abbreviations)
Phenotypes of KO mice
Molecular functions (section
number)
(A)
N
- Glycans
GlcNAcT - I (GnT - I, Mgat - 1)
embryonic lethality
unknown, multiple ( 23.2.4 )
GlcNAcT - II (GnT - II, Mgat - 2)
neonatal death
unknown, multiple ( 23.2.4 )
GlcNAcT - III (GnT - III, Mgat - 3)
no apparent change
unknown ( 23.1 )
GlcNAcT - IVa (GnT - IVa, Mgat - 4a)
type 2 diabetes
modifi cation of glucose transporter 2
to restrain their endocytosis (23.2.6)
GlcNAcT - V (GnT - V, Mgat - 5)
suppression of tumori-
genesis, enhancement of
T cell response
modifi cation of cytokine receptors to
restrain their endocytosis (23.2.6)
α
6 - FucT (FucT - VIII, Fut8)
neonatal semilethality,
growth retardation, em-
physema
modifi cation of cytokine receptors
for their ligand binding (23.2.4)
anemia corresponding to
human HEMPAS
unknown, multiple ( 23.2.5 )
α
- mannosidase II (MII)
male sterility
adhesion between germ cells and
Sertoli cells (23.2.5)
α
- mannosidase IIx (MX)
neonatal semilethality,
growth retardation, IgA
nephritis
unknown, multiple ( 23.2.5 )
β
4GalTI
β
Gal
α
2,6 - sialyltransferase (ST6Gal - I)
impaired B cell func-
tion
production of CD22 ligand to mask
CD22 ( 23.2.4 )
(B)
O
- Glycans
(B.1)
O
- GalNAc (mucin type)
polypeptide GalNAcT
no
apparent
change
unknown, multiple ( 23.1 )
(single KO)
core 2 GlcNAcTI (C2GnT - I)
disorder
of
leukocyte
production of selectin ligand (23.2.2)
traffi cking
α
3 - FucTIV (FucT - IV, Fut4)
disorder
of
leukocyte
production of selectin ligand (23.2.2)
traffi cking
α
3 - FucTVII (FucT - VII, Fut7)
disorder
of
leukocyte
production of selectin ligand (23.2.2)
traffi cking
GlcNAc 6 - sulfotransferase - I
disorder
of
leukocyte
production of selectin ligand (23.2.2)
traffi cking
HEC - GlcNAc 6 - sulfotransferase (LSST)
disorder
of
leukocyte
production of selectin ligand (23.2.2)
traffi cking
Gal
β
3GalNAc sialyltransferase (ST3Gal - I)
decrease of CD8
+
T cells
caused by apoptosis
modifi cation of CD8 to regulate the
binding to MHC class I
(B.2)
O
- Fuc (Notch signaling system)
protein
O
-FucT 1 (PoFucT 1, pofut 1)
embryonic lethality
chaperone and modifi cation of Notch
abnormality
in
somite
modifi cation of Notch
β
3 - GlcNAcT (Lunatic fringe)
formation
β
3 - GalT (Brainiac)
embryonic lethality
unknown
continued
