Chemistry Reference
In-Depth Information
Table 19.2
Continued
Activity
Example of lectin
Recognition of foreign or aberrant glycosig-
natures on cells (incl. endocytosis or ini-
tiation of opsonization or complement
activation)
Collectins, fi colins, C - type macrophage and
dendritic cell lectins, CR3 (CD11b/CD18, Mac-1
antigen),
α
/
θ
- defensins, pentraxins (CRP, limu-
lin), RegIII
γ
(HIP/PAP), siglecs, tachylectins
Targeting of enzymatic activity in multi-
modular proteins
Acrosin, C - terminal
- sandwich lectin domain
of mouse peptide-
N
- glycanase,
Limulus
coagula-
tion factor C, laforin,
β
- trefoil fold [(QxW)
3
domain] of GalNAc-Ts involved in mucin-type
O
-glycosylation (frequent in microbial glycosyl-
hydrolases for plant cell wall polysaccharides)
β
Bridging of molecules
Galectins, C - type lectins, cerebellar soluble lec-
tin
Induction or suppression of effector release
(H
2
O
2
, cytokines etc.)
Galectins, selectins and other C-type lectins such
as CD23, BDCA-2 and dectin-1, I-type lectins
[CD33 (siglec - 3), siglecs - 7 and - 9], Toll - like recep-
tor - 4
Modulation of enzymatic activities/recep-
tor endocytosis via glycan recognition
Mannan - binding lectin (acting on neprins),
galectins (acting on growth factor receptors)
Cell growth control, induction of apopto-
sis/anoikis and axonal regeneration
Galectins, C - type lectins, amphoterin - like pro-
tein, hyaluronic acid-binding proteins, cerebellar
soluble lectin, CD22 (siglec-2), MAG (siglec-4)
Cell migration and routing
Galectins, selectins and other C - type lectins, I -
type lectins, hyaluronic acid-binding proteins
(RHAMM, CD44, hyalectans/lecticans)
Cell - cell interactions
Selectins and other C - type lectins such as DC -
SIGN, galectins, I - type lectins (siglecs, N - CAM,
P
0
or L1), gliolectin
Cell - matrix interactions
Galectins, heparin - and hyaluronic acid - binding
lectins including hyalectans/lecticans, calreticu-
lin
Matrix network assembly
Proteoglycan core proteins (C - type CRD and G1
domain of hyalectans/lecticans), galectins (for
example galectin-3/hensin), nonintegrin 67-kDa
elastin/laminin - binding protein
