Chemistry Reference
In-Depth Information
Table 19.1
Continued
Type of fold
Example for lectin
Example for ligand
a
β
- Trefoil
a) Fibroblast growth factors
b) Cysteine - rich domain of
C - type macrophage man-
nose receptor
c) Lectin domain in GalNAc -
Ts
c
involved in mucin - type
O - glycosylation
d) Hemolytic lectin CEL - III
of sea cucumber and lectin
EW29 of earthworm
Heparan sulfate
GalNAc - 4 - sulfate in LacdiNAc
GalNAc
Gal
β
- Propeller
a) 4 - bladed: tachylectin - 3
b) 5 - bladed: tachylectin - 2
c) 6 - bladed: tachylectin - 1
S - type lipopolysaccharide
GlcNAc/GalNAc
Gram - negative lipopolysaccharide (2 - keto - 3 deoxy-
octonate: Kdo)
β
- Prism II
Pufferfi sh (fugu) lectin
Man
β
- Barrel with jelly - roll to-
pology
Horseshoe crab tachylectin - 4,
eel (
Anguilla anguilla
) aggluti-
nin,
Xenopus
X - epilectin
Fuc
Fibrinogen - like domain
a) Ficolins
b) Intelectins (mammalian,
Xenopus
)
c) Tachylectin - 5
d) Slug (
Limax fl avus
) lectin
GlcNAc
Gal
f
, pentoses
N - Acetylated sugars
Sialic acid
Link module
CD44, TSG - 6, LYVE - 1, aggre-
gating proteoglycans
Hyaluronic acid
Hevein - like domain
Tachycytin and spider (
Sele-
nocosmia huwena
) neurotoxin;
cobra venom cardiotoxin
GlcNAc
Heparin - derived disaccharide
(
)
8
Barrel
(glycoside hydrolase family
18)
β
/
α
YKL - 40 (human cartilage
glycoprotein - 39, chitinase - like
lectin)
(GlcNAc)
n
Lectin domain of mouse latro-
philin - 1, a G - protein - cou pled
receptor
Rha
α
/
β
- Fold
with
two
long
structured loops
Short consensus repeat
(complement control pro-
tein module)
Factor H (complement regu-
lator)
Glycosaminoglycans, sialic acid
a
For abbreviations of names for sugars, please see Chapter 1 .
b
Carbohydrate recognition domain.
