Chemistry Reference
In-Depth Information
Table 18.2
Overview of protein folds with lectin activity.
Type of fold
Example for lectin
a
Example for ligand
a
(a) Calnexin, calreticulin
(b) Leguminous lectins (ConA,
PHA, PNA, PSA, SBA and
others)
Glc
1
Man
9
GlcNAc
2
please see Table 18.1 for
details
β
- Sandwich (jelly - roll)
β
- Trefoil
(a) Lectin subunit of plant AB -
toxins (ricin)
(b) Amaranthin (
Amaranthus cau-
datus
)
Gal
T antigen
β
- Prism I
Jacalin (
Artocarpus integrifolia
),
Maclura pomifera
agglutinin
Artocarpin (
Artocarpus integrifolia
)
and
Musa acuminata, Calystegia
sepium
and
Helianthus tuberosus
agglutinins
T antigen
Glc/Man (linear or bran-
ched
α
- mannans/
α
- glu-
cans)
β
- Prism II
GNA, bluebell (
Scilla campanu-
lata
), daffodil (
Narcissus pseudonar-
cissus
) and garlic (
Allium sativum
)
agglutinins
Man
Hevein - like domain
Rubber tree (
Hevea brasiliensis
) and
stinging nettle (
Urtica dioica
) agglu-
tinins, WGA
(GlcNAc)
n
(
)
8
Barrel (glycoside hy-
drolase family 18)
β
/
α
Black locust (
Robinia pseudoaca-
cia
) chitinase - related agglutinin;
orthologs in
Glycine max, Lotus
japonicus
and
Medicago truncatula
Pentasaccharide
core
of
complex - type
N
- glycans
Lysin motif (LysM) domain
(
Receptor - like kinases in rice,
Ara-
bidopsis thaliana, Medicago trun-
catula
and
Lotus japonicus
CEBiP
(rice)
Lipochitooligosaccharides
(Nod factors)
β
α
α
β
secondary structure)
Chitin oligomer elicitor
a
For abbreviations of names of sugars, please see Chapter 1, for those of names of lectins, please
see Table 18.1. Fungal lectins have four additional folds, further extending the number of folds
with lectin activity: (i) 6- bladed
- propeller (
Psathy-
rella velutina
), (iii) pseudo - h - type fold (
Flammulina velutipes
), (iv) actinoporin-like fold (
Agaricus
bisporus
) .
β
- propeller (
Aleuria aurantia
), (ii) 7 - bladed
β
