Bacterial and Viral Lectins - The Sugar Code - page 288

Lectin type Virus type and species tropism Carbohydrate specifi city a Tissue tropism Infectious diseases

HA Infl uenza A, human Neu5Ac 2,6LacNAc (H3

strains mainly Neu5Ac,
H1 strains also the GlcNAc
and Gal residues in hu-
mans)

α Respiratory tract epithelial cells Upper/lower respiratory tract in-

fections, myalgia (pneumonia and
encephalitis)

Infl uenza A, avian Neu5Ac α 2,3LacNAc, Intestine (bird), respiratory tract

epithelial cells (humans)

Normally symptom free (birds)

Neu5Ac

Infl uenza A, equine and porcine Respiratory tract Respiratory tract

Neu5Ac α 2,3Gal, NeuGc

Infl uenza B, human and seal Neu5Ac α 2,6LacNAc Respiratory tract epithelial cells Upper/lower respiratory tract in-

fection, pneumonia and encephali-
tis

HA - esterase
fusion protein
(HE)

Infl uenza C, human and pig group Neu9Ac Respiratory tract epithelial cells Respiratory tract infection

2 coronavirus, torovirus, human Neu5,9Ac2 Respiratory tract epithelial cells Upper/lower respiratory tract in-

fec tion, gastroenteritis

VP1 Noro - and Norwalk virus, human H type 1, H type 2, H type

3, Le a , Le b , Le x , Le y , blood
group A and B antigens

Small intestine enterocytes Winter vomiting disease, gastroen-

teritis

Simian virus 40, monkey and pos-
sibly human

GM1, GM1 - Gc Broad tropism for primate cells

(utilizing major histocompatibil-
ity complex I as receptor)

Possibly tumorigenic

Human BK virus Transplanted organs, mainly kid-

ney

Nephritis and cystitis in immuno-
compromised individuals

α 2,3 - linked sialic acid on

N - glycans, GD1b, GT1b

Murine polyoma virus GD1a, GT1b Mouse fi broblasts Oncogenic, induce solid tumors

VP3 Adeno - associated virus 2, human HS Kidney Disease is clinically unknown

Adeno - associated virus 4, human Retinal pigment epithelium, cen-

tral nervous system

α 2,3 - linked sialic acid on

O - glycans

Adeno - associated virus 5, human α 2,6 - linked sialic

acid on N - glycans

2,3 - and α Retinal pigment epithelium, pho-

toreceptor cells

Adeno - associated virus 1 and 6, hu-
man

α 2,3 - and α 2,6 - linked sialic Skeletal muscle

acid, HS

VP4 (VP8 * part) Rotavirus, human and pig Neu5Ac, GM3 Enterocytes on the tip of the

intestinal villi

Gastroenteritis