Chemistry Reference
In-Depth Information
Table 15.1
Continued
1960
Detection of the mitogenic potency of lectins toward lymphocytes (P.C. Nowell)
1963
Introduction of affi nity chromatography for the isolation of lectins, published in 1965 (I.J. Gold-
stein, B.B.L. Agrawal)
1968-1974
Detection of rapid serum clearance of asialoceruloplasmin in rabbits and isolation of a Gal/
GalNAc - specifi c
lectin
(asialoglycoprotein
receptor)
from
liver - the
fi rst mammalian lectin
(G. Ashwell, A.G. Morell
et al.
)
1972
Determination of the amino acid sequence and the three-dimensional structure of a lectin -
concanavalin A or ConA (G.M. Edelman, K.O. Hardman, C.F. Ainsworth
et al.
)
1972-1977
Detection of impaired synthesis of a marker for glycoprotein (lysosomal enzymes) routing as
cause for a human disease (mucolipidosis II) and its identifi cation as mannose - 6 - phosphate, the
ligand for P-type lectins (E.F. Neufeld
et al.
; W.S. Sly
et al.
)
1978
First conference focusing on lectins and glycoconjugates, termed Interlec (T.C. Bøg-Hansen)
1979
Detection of endogenous ligands for plant lectins (H. Rüdiger)
1981 - 1988
Further refi nements of the defi nition of the term 'lectin' as carbohydrate-binding protein,
separated from antibodies and carbohydrate-processing enzymes/sensor or transport proteins for
free sugars (S.H. Barondes, I.J. Goldstein, J. Kocourek
et al.
)
1982
Introduction of serial lectin affi nity chromatography as analytical tool for structural analysis of
glycans from glycoproteins (R.D. Cummings, S. Kornfeld)
1983
Detection of the insecticidal action of a plant lectin (L. L. Murdock)
1984
Isolation of lectins from tumors (H.-J. Gabius; R. Lotan, A. Raz)
1985
Immobilized glycoproteins as pan - affi nity adsorbents for lectins (H. Rüdiger)
1989
Detection of the fungicidal action of a plant lectin (W.J. Peumans)
1992/93
Detection of impaired synthesis of lectin (selectin) ligands by defective fucosylation as cause
for leukocyte adhesion defi ciency type II, a congenital disorder of glycosylation (CDG IIc)
(A. Etzioni
et al.
)
1995
Structural analysis of a lectin-ligand complex in solution by nuclear magnetic resonance
spectroscopy (J. Jim é nez - Barbero
et al.
)
1996-2003
Detection of differential conformer selection by plant, bacterial and animal lectins (H.-J. Gabius
et al.
; L. Poppe
et al.
)
2001 - 2005
Development of glycan/lectin microarrays for specifi city analysis of lectins/structural analysis of
glycans and glycoproteomics (various laboratories worldwide)
2001-2009
Advances in lectinology and glycosciences honored by devoting special issues in
Advanced Drug
Delivery Reviews, Biochemical Society Transactions, Biochimica et Biophysica Acta, Biochimie, Biological
Chemistry, Cells Tissues Organs, Chemical Reviews, Current Opinion in Structural Biology, Glyco-
