Pollution and Pollution Control - Environmental Biotechnology: Theory and Application - page 70

There are two main mechanisms, often labelled 'direct' and 'indirect'. In the
former, the effect arises by the contaminant combining with cellular constituents
or enzymes and thus preventing their proper function. In the latter, the damage
is done by secondary action resulting from their presence, typified by histamine
reactions in allergic responses.
The significance of natural cycles to the practical applications of environmen-
tal biotechnology is a point that has already been made. In many respects the
functional toxicity of a pollution event is often no more than the obverse aspect
of this same coin, in that it is frequently an overburdening of existing innate
systems which constitutes the problem. Thus the difficulty lies in an inability to
deal with the contaminant by normal routes, rather than the simple presence of
the substance itself. The case of metals is a good example. Under normal cir-
cumstances, processes of weathering, erosion and volcanic activity lead to their
continuous release into the environment and corresponding natural mechanisms
exist to remove them from circulation, at a broadly equivalent rate. However,
human activities, particularly after the advent of industrialisation, have seriously
disrupted these cycles in respect of certain metals, perhaps most notably cadmium,
lead, mercury and silver. While the human contribution is, clearly, considerable,
it is also important to be aware that there are additional potential avenues of
pollution and that other metals, even though natural fluxes remain their dominant
global source, may also give rise to severe localised contamination at times.
The toxicity of metals is related to their place in the periodic table, as shown in
Table 4.1 and reflects their affinity for amino and sulphydryl groups (associated
with active sites on enzymes).
In broad terms, type-A metals are less toxic than type-B, but this is only
a generalisation and a number of other factors exert an influence in real-life
situations. Passive uptake by plants is a two-stage process, beginning with an
initial binding onto the cell wall followed by diffusion into the cell itself, along
a concentration gradient. As a result, those cations which readily associate with
particulates are accumulated more easily than those which do not. In addition,
the presence of chelating ligands may affect the bio-availability and thus, the
resultant toxicity of metals. Whereas some metal-organic complexes (Cu-EDTA
for example) can detoxify certain metals, lipophilic organometallic complexes
can increase uptake and thereby the functional toxic effect observed.

Table4.1 Metalperiodicityandtoxicity

Metal group Relative toxicity

Group IA Na < K < Rb and Cs

Group IB Cu < Ag < Au

Group IIA Mg < Ca < Sr < Ba

Group IIB Zn < Cd < Hg

Group IIIA Al < Ga < In < Tl